Reverse mutations occur which change the mutated sequence back to the original wild type sequence.
2.
:: I always thought of X-Men as having that controversy embedded in metaphor; i . e ., X-Men : The Last Stand makes a clear point that, although there " is " a method for reversing mutations, the mutation of itself isn't necessarily a disease.
3.
This " supercharged " the Legacy cure, simultaneously killing him and stopping the spread of the Legacy virus, instanteously curing even those dying of the virus at that moment ( Although it was later revealed Colossus had been resurrected by alien technology and was being used as a test subject for an experimental formula that would reverse mutations before he was rescued by the X-Men ).